Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age‐associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we (...) emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets. Copyright Line: © 2015 The Authors BioEssays Published by Wiley‐VCH Verlag GmbH & Co. KGaA. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Peirce’s doctrine of God has scarcely been studied at all. This is surprising because his own naturally religious temperament, his desire for philosophical completeness and the influence of Kant, all led him to give an important place to theistic speculation in his philosophy. It is true that few parts of his philosophy reveal more than the fragmentary and unfinished nature of his thinking. This however does not take away from its importance both for the interpretation of his philosophy and for (...) the evaluation of its contribution. In this paper I want to examine his doctrine of God mainly in order to discover and outline what views he held in the matter. Such examination is an essential preliminary to any consideration of the value of his theistic thinking. Moreover, an objective exposition is already the best beginning of evaluation. However it is impossible to undertake this kind of examination without a careful search into various corners of his writings and a meticulous and slightly laboured presentation of one’s findings. But I think that the patience involved in such research has a rich reward. (shrink)

By analyzing the parallels between Sappho's Brothers Song and archaic Greek songs of welcome, especially Archilochus fr. 24 West, this essay offers a new interpretation of the Brothers Song. It clarifies that ἔλθην in the first preserved stanza represents an original aorist indicative. The chatterer repeats over and over a welcome song that begins, “Charaxus arrived with a full ship.” The rest of the song continues to engage with the welcome song tradition, anticipating the welcome song that will celebrate Charaxus' (...) return to Mytilene, when and if that occurs. By pointing beyond itself to other, real or notional, songs about Charaxus, the Brothers Song also demonstrates Sappho's nonlinear method of storytelling that relies on her audiences' imaginations. (shrink)

Alone among surviving Athenian homicide orations, Antiphon'sOn the Murder of Herodesresembles a modern murder mystery. Antiphon's client, a Mytilenean named Euxitheus, tells a story of a stormy night, an isolated harbour, a drunken murder victim, a missing corpse, misleading bloodstains, forged documents and hints of political intrigue. And, like in any good whodunnit, Euxitheus insists that no one knows who the killer is. Although all the clues seem to point to him, he maintains that Herodes' relatives have manipulated the evidence (...) to make him seem guilty. We do not know whether Euxitheus succeeded in convincing his jurors, but the author of theLife of Antiphonattributed to Plutarch, who says that Antiphon was ‘adept in situations with no way out’ (ἐν τοῖς ἀπόροις τεχνικός), considersOn the Murder of Herodesone of Antiphon's finest compositions (832E, 833D). (shrink)

Essays in Memory of Richard Helgerson: Laureations brings together new essays by leading literary scholars of the British and European middle ages and early modern period who have been influenced by the groundbreaking scholarship of Richard Helgerson. The contributors evince the ongoing impact of Helgerson's work in critical debates including those of nationalism, formal analysis, and literary careerism.

Against the view of some contemporary Kantians who wish to downplay Kant's retributivist commitments, I argue that Kant's theory of practical of reason implies a retributive conception of punishment. I trace this view to Kant's distinction between morality and well-being and his attempt to synthesize these two concerns in the idea of the highest good. Well-being is morally valuable only insofar as it is proportional to virtue, and the suffering inflicted on wrongdoers as punishment for wrongdoing is morally good so (...) long as it is proportional to the wrongdoing. According to Kantian retributivism, punishment is warranted as a means to promote proportionality between well-being and virtue. (shrink)

Ragnar Rommetveit University of Oslo Let me start this introduction to Professor O'Connell's Critical essays on language use and psychology with some reflections on psychologists and crabs. It so happens that the first professor of psychology in Norway had the middle name Krabbe ("Crab") His full name was Harald Krabbe Schjelderup. Hence, the crab became our symbol for the psychologist. For many years a "crab feast" was held every autumn in Oslo in order to celebrate the material union of crabs (...) and psychologists and ponder (symbolically and metaphorically) their shared fate. A comparison between the predicament of the crab and that of the modern psychologist may indeed be illuminating, once we make certain assumptions about their unique epistemic missions and systematically explore the severe constraints on their heroic search for knowledge. The crab is ordained to unravel the mysteries of the ocean, yet doomed to crawl sidewise on the is most of the time mollusks and bottom. His catch, alas, cadavers of sea creatures, and he cannot help envying the fish swimming freely above him. The psychologist's mission is to unravel the mysteries of His obligation to seek insight into essential the human soul. (shrink)

A globe-spanning investigation into the Transhumanist movement, considering the tech billionaires, scientific luminaries, and DIY body-hackers attempting to prolong, improve, and ultimately transcend the limits of human life.

This book rounds off the study of St. Augustine's view of the human condition which Fr. O'Connell began in St. Augustine's Early Theory of Man, A.D. 386-391, and continued in St. Augustine's Confessions: The Odyssey of Soul. The central thesis of that first book, and the guiding hypothesis of the second, proposed that Augustine thought of us in "Plotinian" terms, as "fallen souls," and that he interpreted, in all sincerity, the teachings of Scripture as reflecting that same view. O'Connell sees (...) the weightiest objection to his proposal as stemming from what scholars generally agree is Augustine's firm rejection of that view in his later works. The central contention here is that Augustine did indeed reject his earlier theory, but only for a short while. He came to see the text from Romans 9, 11 as apparently compelling that rejection. But then his firm belief that all humans are guilty of original sin would have left him traducianism as his only acceptable way of understanding the origin of sinful human souls. The materialistic cast of traducianism, however, always repelled Augustine. Hence, he struggles to elaborate a fresh interpretation of Romans 9,11, and eventually he finds one that permits him to return to a slightly revised version of his earlier view. That theory, O'Connell argues, is encased in both the De Civitate Dei and the final version of the De Trinitate. This terse summary barely hints at the richness of detail contained here: O'Connell beginswith a minute analysis of the third book of the De Libero Arbitrio, then of the letters and works ostensibly supporting rival chronological patterns which he must overturn in order to make his case. Finally, in the light of his findings, he offers fresh interpretations of Augustine's three mature masterpieces, On Genesis, The Trinity, and City of god. These, along with Fr. O'Connell's contention that Augustine's anti-Pelagian De Peccatorum Meritis et Remissione must have seen publication no earlier than A.D. 416/17, will doubtless fuel scholarly debate for some time to come. Indeed, Pelagianism made the question of the soul's origin so pivotal for Augustine, that few of our current interpretations of Augustine are likely to remain unaffected by the results of O'Connell's searching and provocative study. (shrink)

Assuming that the reader accepts, albeit provisionally, that James's "will" to believe, early and late, implies that his ethics is traversed by a deontological streak, and by a "faith" which implies epistemic form on the relevant facts (both interpretations the writer argued for in two previous essays), a final feature of his position entitles one to interpret his "will" to believe as, not merely a willingness or readiness, but as a controlling resolve, in the strong sense, to interpret the facts (...) in a manner appropriate to our living in the "strenuous mood," a mood which is congruent to our universe viewed as "moral." Consider, as a crucial instance, the will to believe which undergirds the "keeping" of a friendship. (shrink)

The spatial dynamics of the optical emission from an array of 50 times 50 individual microcavity plasma devices is investigated. The array is operated in argon and argon-neon mixtures close to atmospheric pressure with an ac voltage. The optical emission is analysed with phase and space resolution. It has been found that the emission is not continuous over the entire ac period, but occurs once per half period. Each of the observed emission phases shows a self-pulsing of the discharge, with (...) several bursts of emission of fixed width and repetition rate. The number of emission bursts depends on applied voltage and frequency. Spatially resolved measurements prove that the emission bursts are formed by overlapping emission pulses from single discharge cavities. Intensity differences between positive and negative half-wave can be interpreted through spatially resolved measurements of single discharge cavities. (shrink)

A narrative history of Oxford Movement, whereby a group of Anglican intellectuals, notably Newman, Pusey, Keble and Froude, attempted to restore to the Victorian Church of England the character of primitive Christianity. Many of the inherent principles, such as Apostolic Succession, were seen to be exemplified by the Catholic Church.

This paper considers two contenders for the title of highest good in Kant's theory of practical reason: happiness proportioned to virtue and the maximization of happiness and virtue. I defend the against criticisms made by Andrews Reath and others, and show how it resolves a dualism between prudential and moral practical reasoning. By distinguishing between the highest good as a principle of evaluation and an object of agency, I conclude that the maximization of happiness and virtue is a corollary of (...) the instantiation of the proportionality thesis. (shrink)

In this editorial, we argue that midwives should focus on climate change, a link which has been underexplored.

This Element is a philosophical history of Social Darwinism. It begins by discussing the meaning of the term, moving then to its origins, paying particular attention to whether it is Charles Darwin or Herbert Spencer who is the true father of the idea. It gives an exposition of early thinking on the subject, covering Darwin and Spencer themselves and then on to Social Darwinism as found in American thought, with special emphasis on Andrew Carnegie, and Germany with special emphasis on (...) Friedrich von Bernhardi. Attention is also paid to outliers, notably the Englishman Alfred Russel Wallace, the Russian Peter Kropotkin, and the German Friedrich Nietzsche. From here we move into the twentieth century looking at Adolf Hitler - hardly a regular Social Darwinian given he did not believe in evolution - and in the Anglophone world, Julian Huxley and Edward O. Wilson, who reflected the concerns of their society. (shrink)

This paper explores possible connections between gender and the willingness to engage in unethical business behavior. Two approaches to gender and ethics are presented: the structural approach and the socialization approach. Data from a sample of 213 business school students reveal that men are more than two times as likely as women to engage in actions regarded as unethical but it is also important to note that relatively few would engage in any of these actions with the exception of buying (...) stock with inside information. Fifty percent of the males were willing to buy stock with insider information. Overall, the results support the gender socialization approach. (shrink)

The Clinton Administration stated that the list of values and moral principles generated by the Ethics group reflects "fundamental national beliefs about community, equality, and liberty" and that "these convictions anchor health reform in shared moral traditions." However, these statements are difficult to justify. There is not a moral consensus in America that would justify thorough-going health care reform. In such a context of pluralism, ethicists should seek to move society in the direction of solidarity. The participation of ethicists on (...) the Clinton Task Force was valuable because it showed that health reform is an exercise in social ethics, disseminated the work of ethicists to the entire Task Force, and expanded the experience of the ethicists involved. It may also have accelerated the moral transformation of Americans, which is needed before radical reform can take place. Keywords: American values, Clinton health plan, health care reform CiteULike Connotea Del.icio.us What's this? (shrink)

The evidence for the effectiveness of rehabilitation of three types of attention—selectivity, sustained attention, and attentional switching—is reviewed. Limited but significant effects in all three domains are observed, though evidence for generalization to wider everyday life functions remains relatively sparse. In the case of sustained attention and also in the case of spatial selectivity, the modulating effects of arousal are shown to be important, and higher level executive deficits may at times be exacerbated or even caused by lowered levels of (...) arousal. Conversely, methods of modulating arousal may be used to improve sustained attention and executive functions in a range of clinical conditions. Attentional functions are key to other cognitive domains such as attention and perception, and so the promising evidence for attentional rehabilitation may contribute to the rehabilitation of other cognitive domains also. (shrink)

As a young student in Paris, O'Connell was first enamored of the intriguing artistic imagery of Augustine's works. The imagery continued to impress him as his scholarship continued. Now, after many years of research and regarding study on the topic, a thorough treatment of Augustine's "image clusters" is revealed in this volume, Soundings in St. Augustine's Imagination. That St. Augustine's writings are empowered by use of poetic imagery is of interest to readers of philosophy, theology, as well as language. In (...) this work, Augustine's imagery is used as a basis to shed light on some of his thought which had previously puzzled the scholarly world. Soundings in St. Augustine's Imagination is an imperative addition to any philosophical library and a rich reward for all intrigued by his dramatic use of language and metaphor. (shrink)

This paper argues that cool is a virtue in a specific context: that of black Americans living under a specific modality of white supremacy. But cool is not merely a coping mechanism. A historical analysis of the term shows that cool is being unimpressed by, and calm in the face of, white supremacy. This is made manifest in a style, the “cool pose,” the sophistication of which is captured in the jazz of Lester Young and Miles Davis. Thus, cool is (...) both a virtue of character and a feature of black American aesthetics. But as a cultural phenomenon, it has been appropriated by white American culture. (shrink)

Terry O’Connell helped pioneer restorative justice in Australia, the United Kingdom and North America. A 30-year police veteran, he worked with the Thames Valley Police service developing restorative practices in the UK, including its use in police agency complaints and discipline systems. O’Connell is responsible for the creation of the Real Justice conference script, a Socratic approach that focuses on asking restorative questions. O’Connell realized that letting people talk about how they were affected by the actions of (...) others wasmore effective than blaming and punishing offenders. As director of Real Justice Australia, an IIRP program, he has expanded this model to a range of family, community, institutional and workplace settings. In schools in particular, restorative practices has been a catalyst for change, helping teachers, students and parents strengthen relationships, improve school culture and reduce discipline problems. (shrink)

When Dr. van Fleteren writes of the articles I criticized as dating from some twenty years ago, the unwary reader might infer that my criticism of those articles was, for its part, relatively recent. The fact is, however, that when the two connected articles I eventually criticized appeared in the volumes of Augustinian Studies, I wrote this reply while Fr. Robert Russell, of happy memory, was still at the helm, and was promised publication in the near future. Meanwhile, however, Fr. (...) Russell had the discourtesy to move on to a more intimate acquaintance with Augustine than any of us on this confused planet can boast of, and someone sowed cockle into field he had tended: in unaccountable fashion my article seems to have disappeared. Only a recent letter of inquiry on my part, and Fr. Allan Fitzgerald’s understanding reply, resulted in this renewal of dialogue between Dr. van Fleteren and me. Let me assure both Dr. van Fleteren and Fr. Fitzgerald that I am grateful for giving it exactly that form, a courteous dialogue. (shrink)

“... it ain't likely to have a radius of exactly zero,” is the conclusion of H. G. Dehmelt(1) from his Nobel Prize (1989) winning observations on trapped electrons. There are small discrepancies between Dehmelt's observations and the theoretical predictions of quantum electrodynamics (QED), which assumes that the electron is a point particle. Here we present evidence in support of Dehmelt's contention that the electron has a structure. Essentially, we point out that the nonrelativistic limit of QED is at variance with (...) a fundamental principle underlying all of physics, viz. the second law of thermodynamics. (shrink)

If we can wrong a work of art, then it has moral status. This paper considers two examples of putative wrongings of works of art, but in both cases, the claim that the work of art itself is wronged cannot be vindicated. The sense that a work of art has been wronged arises when that work has a special meaning for us or has a special standing in a cultural context. There is nothing intrinsic to works of art that can (...) confer moral status upon them, and so they are not moral patients. (shrink)